The One Pot Synthesis and Antioxidant Activity Determination of Novel Molecules
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Alzheimer's disease affects many people today. For this reason, the economic and social burdens of the disease on society are also increasing. Although the cause of the disease has not been fully clarified yet, many factors are suggested in this regard. One of the most striking among these is brain deformations as a result of oxidative stress. In this study, three new molecules, (E/Z) - (4-fluorophenylthio) -N-(4-methoxybenzylidene) (4-methoxyphenyl) methenamine (NS-1), (E/Z) - (4-fluorophenylthio) -N-(4-hydroxybenzylidene) (4-hydroxyphenyl) methenamine (NS-2), and (E/Z) - (4-fluorophenylthio) -N-(2-pyyrolidene) (2-pyrrole) methenamine (NS-3) were synthesized and their antioxidant properties were evaluated using CUPRAC method and Trolox equivalent antioxidant capacity coefficients were determined. The antioxidant capacity of NS-3, was found to be considerably higher than torolox, 1.5. The Cyclic voltammetry (CV) of compounds was achieved within the potential range -1.4V to 0.95 V with a 50 mVs-1 scan rate. 82.15 μA at 456 mV and -929 mV for 10-4 M NS-3 reduction peaks with current values of -104.9 μA were found. The molecule NS-3 can be a potential candidate for antioxidants that could be used to slow the progression of Alzheimer’s disease.
References
-
Kinsella K, Wan H. Census Bureau: International Population Reports, 2009 P95/09-1: An Aging World. Washington, DC: U.S. Government Printing Office; 2008.
Google Scholar
1
-
Alzheimer A. Uber eineeigenartige Erkankung der Hirnrinde. Allg. Zeitschr. Psychiatr. 1907; 64, 146.
Google Scholar
2
-
Alzheimer A, Stelzmann RA, Schnitzlein HN, Murtagh FR. Uber eineeigenartige Erkankung der Hirnrinde. Clin Anat. 1995; 8 (6): 429-31.
Google Scholar
3
-
Ernst RL, Hay JW. The US Economic and Social Costs of Alzheimer’s Disease. J Public Health. 1994; 84 (8): 1261-4.
Google Scholar
4
-
Hölscher C. Possible Causes of Alzheimer’s Disease: Amyloid Fragments, Free Radicals, and Calcium Homeostasis. Neurobiol Dis. 1998; 5 (3): 129-41.
Google Scholar
5
-
Armstrong RA. What Causes Alzheimer’s Disease? Folia Neuropathol. 2013; 51 (3): 169-88.
Google Scholar
6
-
Selkoe DJ. The Genetics and Molecular Pathology of Alzheimer’s Disease: Roles of Amyloid and the Presenilins. Neurol Clin. 2000; 18 (4): 903-22.
Google Scholar
7
-
Lee VM, Goedert M, Trojanowski JQ. Neurodegenarative Tauopathies. Annu Rev Neurosci. 2001; 24: 1121-59.
Google Scholar
8
-
Smith MA, Sayre LM, Monnier VM, PerryG. Radical AGEing in Alzheimer’s Disease. Trends Neurosci. 1995; 18 (4): 172-6.
Google Scholar
9
-
Markesbery WR. Oxidative Stress Hypothesis in Alzheimer’s Disease. Free Radic Biol Med. 1997; 23 (1): 134-47.
Google Scholar
10
-
Christen Y. Oxidative Stress and Alzheimer Disease. Am J Clin Nutr. 2000; 71 (2): 621S-629S.
Google Scholar
11
-
Picklo MJ, Montine TJ, Amarnath V, Neely MD. Carbonyl Toxicology and Alzheimer’s Disease. Toxicol Appl Pharmacol. 2002; 184 (3): 187-97.
Google Scholar
12
-
Varghese JF, Patel R, Yadav UCS. Novel Insights in the Metabolic Syndrome-induced Oxidative Stress and Inflammation-mediated Atherosclerosis. Curr Cardiol Rev. 2018; 14 (1): 4-14.
Google Scholar
13
-
Yaribeygi H, Panahi Y, Javadi B, Sahebkar A. The Underlying Role of Oxidative Stress in Neurodegeneration: A Mechanistic Review. CNS Neurol Disord Drug Targets. 2018; 17 (3): 207-215.
Google Scholar
14
-
Pratico D, Delanty N. Oxidative Injury in Diseases of the Central Nervous System: Focus on Alzheimer’s Disease. Am J Med. 2000; 109 (7): 577-85.
Google Scholar
15
-
Sies H. Oxidative Stress: Oxidants and Antioxidants. Exp Physiol. 1997; 82 (2): 291-5.
Google Scholar
16
-
Huang D, Ou B, Prior RL. The Chemistry behind Antioxidant Capacity Assays. J Agric Food Chem. 2005; 53 (6): 1841-56.
Google Scholar
17
-
Gerçek Z, Ceyhan D, and Erçağ E. Synthesis and Molecular Docking Study of Novel COVID-19 Inhibitors. Turk J Chem. 2021; 45 (3): 704-718.
Google Scholar
18
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