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The aim of the present study was to evaluate the phytochemical constituent and anthelmintic activity of methanolic extract of whole parts of Croton bonplandianum Baill. The various concentration i.e. 100%, 50%, and 25% of methanolic extract of the whole part of Croton bonplandianum Baill were tested for bioassay which determined the time of paralysis (P) the time of death (D) of Pheretima posthuma. Albendazole was used as a standard drug and the normal saline solution was used as controlled. The three different concentrations of plant extract i.e. 25 mg/ml, 50 mg/ml, and 100 mg/ml showed paralysis time 21±1 min, 17±1 min, and 13±2min respectively, and showed death time 51±2 min, 47±1 min, and 41±1 min respectively. Albendazole as a standard drug, in three different concentrations i.e. 25 mg/ml, 50 mg/ml, and 100 mg/ml showed paralysis times 16±1 min, 10±2 min, and 7±2 min respectively, and showed death times 31±2 min, 22±2 min, and 18±3 min respectively. From the result, it is concluded that the methanolic extract of Croton bonplandianum Baill has significant Anthelmintic activity.

References

  1. Camurça-Vasconcelos AL, Bevilaqua CM, Morais SM, Maciel MV, Costa CT, Macedo IT, Oliveira LM, Braga RR, Silva RA, Vieira LS. Anthelmintic activity of Croton zehntneri and Lippia sidoides essential oils. Veterinary Parasitology. 2007 Sep 30;148(3-4):288-94.
     Google Scholar
  2. Divya S, Naveen Krishna K, Ramachandran S, Dhanaraju MD. Wound healing and in vitro antioxidant activities of Croton bonplandianum leaf extract in rats. Global J Pharmacol. 2011;5(3):159-63.
     Google Scholar
  3. Dutta S, Chaudhuri TK. Pharmacological aspect of Croton bonplandianus Baill: A comprehensive review. J. Pharmacogn. Phytochem. 2018;7(1):811- 13.
     Google Scholar
  4. Dutta S, Dey P, Chaudhuri TK. Phytochemical investigation and correlation study of Croton bonplandianus Baill. stem. Journal of Pharmacognosy and Phytochemistry. 2014 May 1;3(1).
     Google Scholar
  5. Tripathi KD, Essentials of Medical Pharmacology, Jaypee Brothers Medical Publishers, New Delhi, 8th edition, 2019, 906-909.
     Google Scholar
  6. Kanthal LK, Mondal P, De S, Jana S, Aneela S, Satyavathi K. Evaluation of anthelmintic activity of carica papaya latex using pheritima posthuma. International Journal of Life Science and Pharma Research. 2012;2(1):10-2.
     Google Scholar
  7. Hapse SA, Pagar HJ, Suruse SD, Ugale SS. In-vitro anthelmintic activity of Croton bonplandianum Baill. Journal of Applied Pharmaceutical Science. 2012; 02(04): 191-3. doi: 10.7324/JAPS.2012.2516.
     Google Scholar
  8. Jabbar A, Zaman MA, Iqbal Z, Yaseen M, Shamim A. Anthelmintic activity of Chenopodium album (L.) and Caesalpinia crista (L.) against trichostrongylid nematodes of sheep. Journal of Ethnopharmacology. 2007 Oct 8;114(1):86-91.
     Google Scholar
  9. Ramachandran G. Pharmacological Evaluation of Whole Plant Extract from Croton Bonplandianum Baill (Doctoral dissertation, Periyar College of Pharmaceutical Sciences, Trichirappalli).
     Google Scholar
  10. John H, Block & John M, Beale Jr. Wilson & Gisevold. Textbook of Organic Chemistry. 11th ed. Philadelphia: Wolters kluwer; 2007 p. 264.
     Google Scholar
  11. Meheta RM. Pharmaceutics-I. Revised 6th ed. Delhi: Vallabh Prakashan; 2018 p. 157- 207.
     Google Scholar
  12. Mali RG. In vitro Anthelmintic activity of stem bark of Mimusops elengi linn. Phcog Mag. 2007; 3 (10): 73-76.
     Google Scholar
  13. Partap S, Kumar S, Kumar A, Sharma NK, Jha KK. In-vitro anthelmintic activity of Luffa cylindrica leaves in Indian adult earthworm. Journal of pharmacognosy and phytochemistry. 2012 Jul 1;1(2):27-30.
     Google Scholar
  14. Jeeva S, Kiruba S, Mishra BP, Venugopal N, Dhas SSM, Regini GS, Kingston C, et al. Weeds of Kanyakumari district and their value in rural life. Indian Journal of Traditional Knowledge, 2006; 5(4): 501-509.
     Google Scholar
  15. Kokate CK, Purohit AP, Gokhale SB. Pharmacognosy. Nirali Prakashan. 2005:6-19.
     Google Scholar