Research Article

Identification and Comparative Study of Invitro Antioxidant Potential of Fractionated Hydroalcoholic Extract of Phyllanthus Niruri Linn

Gayathri Rajamanickam
Vellore Institute of Technology, India.
Manju S. L.
Vellore Institute of Technology, India.
* Corresponding author
DOI icon 10.24018/ejchem.2020.1.1.2

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Submitted 2019-11-20
Published 2020-01-20

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Article Main Content

It is apparent that varieties of plants have the potential to show numerous preventive and therapeutic activities that may be relevant to the treatment of disorders caused by oxidative stress and free radicals. A variety of herbal extracts and their phyto components have been demonstrated to exert antioxidant activities, either by directly stimulating antioxidant response genes or by potentiating the bodies` own natural antioxidant defense mechanism. This study reported the high-performance liquid chromatography, invitro antioxidant activity, measurement of total phenolic and flavonoid contents of various solvent extracts of whole plant of Phyllanthus niruri in order to find possible treatment of disorders caused by oxidative stress such as neurodegenerative diseases. Results obtained revealed that, ethyl acetate fractions of P. niruri whole plants possess high flavonoid and polyphenolic compounds which ultimately leads to the potent antioxidant activity than other polar and nonpolar solvent fractions. Thus, this study suggests that, these fractions can be used as a potent source of natural antioxidant there by it can be used for the further investigation for the treatment of neurodegenerative diseases and other free radical induced pathological conditions.

Keywords: Phyllanthus niruri, HPTLC, ethyl acetate, flavonoid, polyphenol, antioxidant, neurodegenerative disease.

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