Research Article

Synthesis and Antimicrobial Studies of 6-Aryl and 6-Anilino Benzo[a]phenoxazinones

Simon Sani Ocholi
University of Nigeria, Nigeria.
Efeturi Abraham Onoabedje
University of Nigeria, Nigeria.
Samuel Attah Egu
Kogi State University, Nigeria.
* Corresponding author
DOI icon 10.24018/ejchem.2020.1.2.4

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Submitted 2020-04-01
Published 2020-05-22

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Article Main Content

Palladium catalyzed Suzuki-Miyaura (SM) and Buchwald – Hartwig (BH) cross-coupling reactions of some phenoxazines are reported.  The precursor  9,11-diamino-6-chloro-7-oxa-8,10,12-triaza-benzo [a] anthracen-5-one  was prepared by anhydrous base mediated reaction of  2,5,6-triamino-pyrimidin-4-ol  and 2,3-dichloro-1,4-naphthoquinone in methanol. The molecular structures of the synthesized compounds agreed with UV/visible, FT-IR, 1H-NMR, MS and elemental analysis data. Using Ciprofloxacin and Ketoconazole as reference drugs, the compounds were screened against six (6) micro-organisms, viz: Listeria ivanovii, Staphylococcus aureus, Klebsiellapneumoniae, Escherichia coli, Candida albicans and Aspergillusnigerand were found to show significant activity against L.ivanovii and E. coli bacteria.

Keywords: Benzo[a]phenoxazinone, Buchwald–Hartwig, Cross-coupling, Palladium catalyzed, Phenoxazines, Phenothiazines, Suzuki-Miyaura.

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