Synthesis and Applications of β–cyclodextrin Incorporated Carica Papaya Leaf Extract Electrospun Nanofibers


Electrospinning is an easier and more useful technique that uses electrostatic forces to yield very thin fibers of polymer enriched substances in the nanometer range. So many other techniques are used for the synthesis of nanofibers, yet electrospinning has proven to be an efficient method that has a significant effect on their properties. In the present study, the production of polymer enhanced nanofibers of Carica papaya leaf extracts was done using Electrospinning. The supra molecular cyclodextrin incorporated Carica papaya leaf extract nanofibers were also prepared using Electrospinning method. The nanofiber mats were subjected to UV-Visible Spectrophotometer, FT-IR, FESEM and Anti-Bacterial analysis. The studies showed the supramolecular incorporated extract is having more effect as a drug than the normal extract alone.


  1. N. Otsuki, N.H. Dang, E. Kumagai, A. Konda, S. Iwata and C. Morimoto. Aqueous extract of Carica papaya leaves exhibit anti-tumour and Immunodulatory effects. Journal of Ethnopharmacology, 2010;127(3): 760-767.  |   Google Scholar
  2. V. Anjum, P. Arora, S.H. Ansari, A.K. Najmi andS. Ahmad. Antithrombocytopenic and immunodulatory potential of metabolically characterized aqueous extract of carica papaya leaves. Pharmaceutical biology, 2017;55(1):2043-2056.  |   Google Scholar
  3. B. Kavimandanand, M. Saraf. Studies on Biological Efficacy of Various Leaf Extracts of Carica papaya L. International Conference on Global Trends in Engineering, Technology and Management (ICGTETM), 2016: 510-516.  |   Google Scholar
  4. E.F. Romasi, J. Karina and A.J.N. Parhusip. Antibacterial Activiy of papaya Leaf extract against Pathogenic Bacteria. Makara Journal of Technology, 2011;15(2):173-177.  |   Google Scholar
  5. V. Zunjar,R. Prasad, M. Jivaranjani, B. Trivedi. Anti-thrombocytopenic activity of carpaine and alkaloidal extract of Carica papaya Linn Leavesin Bisulfan induced wistar rats. Journal of Ethnopharmacology, 2016;181:20-25.  |   Google Scholar
  6. W. Zhang, M. Chen and G. Diao. Electrospinning β-Cyclodextrin/poly (vinyl alcohol) nanofibrous membrane for molecular capture. Carbohydrate Polymers, 2011;86(3):1410-1416.  |   Google Scholar
  7. S.Z. Hussain, N. Razvi, S.I. Ali and S.M.F. Hasan. Development of quality standard and phytochemical analysis of Carica papaya Linnleaves. Pakistan Journal of Pharmaceutical Sciences, 2018;31(5):2169-2177.  |   Google Scholar
  8. V.B. Oweyele, O.M. Adebukola, A. A. Funmilayo and A.O. Soladoye. Anti inflammatory activities of Ethanolic extract of Carica papaya leaves. Inflammopharmacology, 2008;16:168-173.  |   Google Scholar
  9. Pallavi Singh, Nainika Tanwar, Trisha Saha, Aishwarya Gupta and Sargam Verma. Phytochemical Screening and Analysis of Carica papaya, Agave americana and Piper nigrum. International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706. 2018;7(02).  |   Google Scholar
  10. M.K. Dwivedi, S. Sonter, S. Mishra, D. Kumar Patel and P.K. Singh. Antioxidant, antibacterial activity, and phytochemical characterization of Carica papaya flowers. Journal of Basic and Applied Sciences, 2020;9(23):1-11.  |   Google Scholar
  11. J. B. Harborne, M. Fitokimia and P. Cara. Modern Menganalisis Tumbuhan. Terjemahan Padmawinata, K. Penerbit ITB. Bandung. 2006  |   Google Scholar
  12. J. Ahlawata, V. Kumara and P. Gopinatha. Carica papaya loaded poly (vinyl alcohol)-gelatin nanofibrous scaffold for potential application in wound dressing. Materials Science & EngineeringC, 2019;103.  |   Google Scholar
  13. D. Setyawati, Andayani, U. Yanuhar. Characterization of Fraction of Carica papaya L. Leaves Ethyl Acetate Extract to African Catfish Clarias gariepinus Leucocytes Using UV-Vis, FTIR and GC-MS Methods. International Journal of ChemTech Research, 2016;9(9): 247-253.  |   Google Scholar
  14. T. Kokila, P.S. Ramesh, D. Geetha. Biosynthesis of AgNPs using Carica Papaya peel extract and evaluation of its antioxidant and antimicrobial activities. Ecotoxicology and Environmental Safety, 2016. 134(2): pp. 467-473.  |   Google Scholar
  15. S. Bashaa, Z.V.P. Murthy, B. Jhaa. Sorption of Hg (II) onto Carica papaya: Experimentalstudiesanddesignofbatchsorber. ChemicalEngineeringJournal, 2009;147(3):226–234.  |   Google Scholar
  16. R. Sridhara, S. Ravanan, J.R. Venugopala, S. Sundarrajana,D. Pliszkaa,S.Sivasubramaniane, P.Gunasekarane M. Prabhakarane, K. Madhaiyan, A. Sahayarajc, and S. Ramakrishnaa. Curcumin- and natural extract-loaded nanofibres for potential treatment of lung and breast cancer: in vitro efficacy evaluation, Journal of Biomaterials Science, 2013;25(10):985–998.  |   Google Scholar
  17. R. R Banala , V. B. Nagati, and P. R Karnati, Green synthesis and characterization of Carica papaya leaf extract coated silver nanoparticles through X-ray diffraction, electron microscopy and evaluation of bactericidal properties. Saudi Journal of Biological Sciences, 2015;22(5):637–644.  |   Google Scholar
  18. I. Augustine, J.A. Airaodion, U. Ekenjoku, I. U. Akaninyene, A.U. Megwas. Antibacterial Potential of Ethanolic and Aqueous Extracts of Carica papaya Leaves. Asian Journal of Biochemistry, Genetics and Molecular Biology, 2020;3(3):33-38.  |   Google Scholar
  19. K.Suresh, Antimicrobial and phytochemical investigation of the leaves of Carica papaya L. Cynodondactylon (L.) Pers., Euphorbia hirta L., Meliaazedarach L. and Psidiumguajava L. Ethnobotanical Leaflets, 2008;12(11):84–91.  |   Google Scholar
  20. C. Baskaran, S. Velu, K. Kumaran, The efficacy of Carica papaya leaf extract on some bacterial and a fungal strain by well diffusion method. Asian Pacific Journal of Tropical Distance, 2012. 2(2): pp. 658–662  |   Google Scholar
  21. B.B. Tewari, G. Subramanian, R. Gomathinayagm. Antimicrobial properties of Carica papaya (papaya) different leaf extract against E. coli, S. aureus and C. albicans. American Journal of Pharmacology abd Pharmacotherapy, 2014;1(1):25–39.  |   Google Scholar
  22. N. Nirosha and R. Mangalanayak. Antibacterial Activity of Leaves and Stem Extract of Carica papaya L. International Journal of Advances In Pharmacy, Biology and Chemistry, 2013;2(3):473-476.  |   Google Scholar
  23. G.Chandra, A.Ghosh, S.K. Chatterjee, I. Bhattacharjee. Antibacterial activities of some plant extracts used in Indian traditional folk medicine. Asian Pacific Journal of Tropical Biomedicine, 2011;1(2):165-169.  |   Google Scholar
  24. A.A. Ogunjobi, and T.E. Ogunjobi, Comparative study of antibacterial activities of Garcinia kola and Carica papaya. African Journal of Biomedical Research, 2011;14 (2):147-152.  |   Google Scholar
  25. E F. Romasi, J. Karina, and A J N. Parhusip, Antibacterial activity of papaya leaf extracts against pathogenic bacteria. Makara Journal of Technology, 2011;15(2):173-177.  |   Google Scholar
  26. T.A. Hema, A.S. Arya, S.Subha, C.R.K. John and P.V. Divya, Antimicrobial activity of five south Indian medicinal plants against clinical pathogens, International Journal of Pharmacology and Biological Sciences, 2013;4(1):70–80.  |   Google Scholar
  27. Z. A. Zakaria, A.M.M. Jais, M.R. Sulaiman, M.S.P.P Isa and S. Riffin. The in vitro antibacterial activity of Carica papaya flowers and Mangifera indica leaves. Journal of Pharmacology and Toxicology, 2006;1(3):278-283.  |   Google Scholar
  28. S.K. Sherwani, T.Z. Bokhan, K. Nazim, S.A. Gilani, and S.U. Kazim. Qualitative phytochemical screening and antifungal activity against human and plant pathogenic bacteria. International Research Journal of Pharmacy, 2013;4(7):1-8.  |   Google Scholar
  29. P. F. Omojasola, and S. Awe. The Antibacterial activity of the leaf extract of Anacardiumoccidentale and Gossyptumhirsutum against some selected microorganisms. Bioscience Research Communication, 2004;16 (1):447-445.  |   Google Scholar

How to Cite

Afinisha Deepam, L. S., Guja, J. B., Aswathy Sudhakar, S., & Paul Raj, L. S. (2022). Synthesis and Applications of β–cyclodextrin Incorporated Carica Papaya Leaf Extract Electrospun Nanofibers. European Journal of Advanced Chemistry Research, 3(1), 87–99.

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 L. S. Afinisha Deepam
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 J. B. Guja
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 S. Aswathy Sudhakar
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 L. S. Paul Raj
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